Endomyocardial biopsy finding in two patients with idiopathic dilated cardiomyopathy receiving long-term treatment with amiodarone
Identifieur interne : 002F76 ( Main/Exploration ); précédent : 002F75; suivant : 002F77Endomyocardial biopsy finding in two patients with idiopathic dilated cardiomyopathy receiving long-term treatment with amiodarone
Auteurs : Eloisa Arbustini [Italie, États-Unis] ; Maurizia Grasso [Italie, États-Unis] ; Jorge A. Salerno [Italie, États-Unis] ; Antonello Gavazzi [Italie, États-Unis] ; Angela Pucci [Italie, États-Unis] ; Manuela Bramerio [Italie, États-Unis] ; Alberto Calligaro [Italie, États-Unis] ; Victor J. Ferrans [Italie, États-Unis]Source :
- The American Journal of Cardiology [ 0002-9149 ] ; 1991.
English descriptors
- Teeft :
Abstract
Abstract: Amiodarone, a highly effective antiarrhythmic agent, accumulates in different tissues, causing a variety of adverse effects.1–3 Long-term amiodarone treatment may cause diffuse interstitial pulmonary fibrosis and inflammation, with accumulation of cytoplasmic bodies containing electron-dense lamellas in pneumyocytes and alveolar macrophages1,2. Similar bodies have been described in liver, lymph nodes, blood leukocytes, cornea, endothelial cells of skin, colonie mucosa,3 and Schwann cells. Such bodies also have been found in cardiac myocytes of experimental animals treated with multiple doses of this drug4,5; however, to our knowledge, they have not been reported in the myocardium of patients treated with amiodarone. This report describes ultrastructural changes in the myocardium of 2 patients with idiopathic dilated cardiomyopathy who had received long-term amiodarone treatment.
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DOI: 10.1016/0002-9149(91)90915-8
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Ferrans</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>From the Departments of Pathology, Cardiology and Histology, IRCCS Policlinico San Matteo, University of Pavia, Via Forlanini 16, 27100 Pavia</wicri:regionArea><wicri:noRegion>27100 Pavia</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>From the Ultrastructure Section, Pathology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">The American Journal of Cardiology</title><title level="j" type="abbrev">AJC</title><idno type="ISSN">0002-9149</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1991">1991</date><biblScope unit="volume">67</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="661">661</biblScope><biblScope unit="page" to="662">662</biblScope></imprint><idno type="ISSN">0002-9149</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9149</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>American journal</term><term>Amiodarone</term><term>Amiodarone treatment</term><term>Aortic</term><term>Aortic dissection</term><term>Aortic valve</term><term>Cardiac</term><term>Cardiac myocytes</term><term>Cardiology</term><term>Cardiomyopathy</term><term>Idiopathic</term><term>Intravascular</term><term>Lamella</term><term>Myocytes</term><term>Ultrasound</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Amiodarone, a highly effective antiarrhythmic agent, accumulates in different tissues, causing a variety of adverse effects.1–3 Long-term amiodarone treatment may cause diffuse interstitial pulmonary fibrosis and inflammation, with accumulation of cytoplasmic bodies containing electron-dense lamellas in pneumyocytes and alveolar macrophages1,2. Similar bodies have been described in liver, lymph nodes, blood leukocytes, cornea, endothelial cells of skin, colonie mucosa,3 and Schwann cells. Such bodies also have been found in cardiac myocytes of experimental animals treated with multiple doses of this drug4,5; however, to our knowledge, they have not been reported in the myocardium of patients treated with amiodarone. This report describes ultrastructural changes in the myocardium of 2 patients with idiopathic dilated cardiomyopathy who had received long-term amiodarone treatment.</div></front></TEI><affiliations><list><country><li>Italie</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="Italie"><noRegion><name sortKey="Arbustini, Eloisa" sort="Arbustini, Eloisa" uniqKey="Arbustini E" first="Eloisa" last="Arbustini">Eloisa Arbustini</name></noRegion><name sortKey="Bramerio, Manuela" sort="Bramerio, Manuela" uniqKey="Bramerio M" first="Manuela" last="Bramerio">Manuela Bramerio</name><name sortKey="Calligaro, Alberto" sort="Calligaro, Alberto" uniqKey="Calligaro A" first="Alberto" last="Calligaro">Alberto Calligaro</name><name sortKey="Ferrans, Victor J" sort="Ferrans, Victor J" uniqKey="Ferrans V" first="Victor J." last="Ferrans">Victor J. Ferrans</name><name sortKey="Gavazzi, Antonello" sort="Gavazzi, Antonello" uniqKey="Gavazzi A" first="Antonello" last="Gavazzi">Antonello Gavazzi</name><name sortKey="Grasso, Maurizia" sort="Grasso, Maurizia" uniqKey="Grasso M" first="Maurizia" last="Grasso">Maurizia Grasso</name><name sortKey="Pucci, Angela" sort="Pucci, Angela" uniqKey="Pucci A" first="Angela" last="Pucci">Angela Pucci</name><name sortKey="Salerno, Jorge A" sort="Salerno, Jorge A" uniqKey="Salerno J" first="Jorge A." last="Salerno">Jorge A. 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Ferrans</name><name sortKey="Gavazzi, Antonello" sort="Gavazzi, Antonello" uniqKey="Gavazzi A" first="Antonello" last="Gavazzi">Antonello Gavazzi</name><name sortKey="Grasso, Maurizia" sort="Grasso, Maurizia" uniqKey="Grasso M" first="Maurizia" last="Grasso">Maurizia Grasso</name><name sortKey="Pucci, Angela" sort="Pucci, Angela" uniqKey="Pucci A" first="Angela" last="Pucci">Angela Pucci</name><name sortKey="Salerno, Jorge A" sort="Salerno, Jorge A" uniqKey="Salerno J" first="Jorge A." last="Salerno">Jorge A. Salerno</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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